In this interview, Shane Shapiro, Mao Clinic, USA, discusses the role of real-world evidence in supporting data from clinical trials and how this being used in the field of regenerative medicine.
About the author:
Shane Shapiro is dedicated to advancing the science of orthopedics and regenerative medicine through research. He is the principal investigator of the world’s first randomized controlled study of bone marrow-derived stem cells to treat knee arthritis — early results of this clinical trial were published in the American Journal of Sports Medicine.
Early in his career, Dr Shapiro worked at the Collins laboratory at the National Institutes of Health (NIH) to map every gene in the human body for the Human Genome Project. Currently, his research focus is to study novel regenerative techniques for chronic nonhealing bone, joint, muscle, tendon and skin maladies that are not candidates for conventional surgical management. Examples include stem cell therapy for arthritis, platelet-rich plasma injections for chronic tendinopathies, and the use of living, cell-based biological applications for chronic nonhealing wounds. Further information on Dr Shapiro’s research is available here.
Video originally published on The Evidence Base from the Future Science Group, a digital platform covering the latest news, opinions and insights concerning the collection and application of real-world data to real-world problems.
Preparing regenerative therapies for clinical application: proposals for responsible translation
Shane A Shapiro, Cambray G Smith, Jennifer R Arthurs & Zubin Master
Regenerative Medicine (2019) doi.org/10.2217/rme-2018-0163